MLB DFS, 2026: Top FanDuel, DraftKings picks, lineups, advice for Friday, April 17, from a daily Fantasy pro

A full slate of 15 games highlights Friday's Major League Baseball schedule, beginning at 2:20 p.m. ET, with the last first pitch set for 9:40 p.m. ET. Among the top options in the MLB DFS player pool include Tyler Glasnow, Joe Ryan, Logan Gilbert, Jacob deGrom, Kyle Tucker, Shohei Ohtani, Mike Trout, Byron Buxton, Aaron Judge, Vladimir Guerrero Jr., Bobby Witt Jr., Corbin Carroll, Daulton Varsho, Elly De La Cruz and Brice Turang. Among those on the injured list include Ryan Mountcastle (foot), Adley Rutschman (ankle), Jose Trevino (back), Isaac Collins (knee), Christian Yelich (groin), Jackson Chourio (hand), Anthony Volpe (shoulder) and George Springer (toe).

Before making any MLB DFS picks on sites like DraftKings and FanDuel for this slate, you need to see what Mike McClure has to say.

McClure is a DFS professional with over $2 million in career winnings. He's also a predictive data engineer at SportsLine who uses a powerful prediction model that simulates every minute of every game 10,000 times, taking factors like matchups, statistical trends and injuries into account.

This allows him to find the best MLB DFS values and create optimal lineups that he shares only at SportsLine. They're a must-see for any MLB DFS player.

For Friday, one of McClure's top MLB DFS picks is Los Angeles Dodgers outfielder Kyle Tucker ($6,400 DraftKings, $4,300 FanDuel). He's also building around Dodgers first baseman/outfielder Shohei Ohtani ($7,000 DraftKings, $4,500 FanDuel). Through 17 games this season, Ohtani has flashed his typical power, though his average is down a bit. He is batting .254 with one double, five homers and 10 RBI. In 158 games last season, he hit .282 with 25 doubles, nine triples, 55 homers and 102 RBI.

McClure is also targeting a player who could go off for massive numbers on Friday! This pick could be the difference between winning your tournaments and cash games or going home with nothing. You absolutely need to see who it is before locking in any lineups.

What are the top MLB DFS picks for Friday? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on MLB DFS!