Memphis vs. South Florida odds, prediction: 2026 American Conference men's college basketball picks from proven model

The South Florida Bulls will look to win their fifth game in a row when they battle the Memphis Tigers in a key American Conference matchup on Thursday. Memphis is coming off a 99-75 loss at Utah State on Saturday, while South Florida downed Florida Atlantic 83-81 on Sunday. The Tigers (12-13, 7-5 American), who have lost two in a row, are 2-8 on the road this season. The Bulls (18-8, 10-3 American), who lead the American, are 10-2 on their home court.

Tip-off from Yuengling Center in Tampa, Fla., is set for 7 p.m. ET. Memphis leads the all-time series 34-8. South Florida is a 8.5-point favorite in the latest Memphis vs. South Florida odds from DraftKings Sportsbook, while the over/under for total points scored is 163.5. Both teams have identical records related to the total this season as each has seen the Over go 13-12.

Before making any Memphis vs. South Florida picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 16 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 13-7 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Memphis vs. South Florida 10,000 times and the results are in. The model is leaning Under, and it also says one side of the spread hits well over 50% of the time!

So who wins Memphis vs. South Florida, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!