Mariners vs. Cardinals odds, line, prediction: 2026 MLB picks for Saturday, April 25, from proven model

The Seattle Mariners will look to extend their winning streak to three games when they take on the St. Louis Cardinals in a key interleague matchup on Saturday afternoon. Seattle is coming off a 3-2 win over St. Louis on Friday night. The Mariners (12-15), who have won four of their last six, are 2-8 on the road this season. The Cardinals (14-11), who have dropped two in a row, are 7-6 on their home field.

First pitch from Busch Stadium in St. Louis is set for 2:15 p.m. ET. The Mariners lead the all-time series 15-13, and have won six of the last seven meetings. Seattle is a -149 favorite on the money line (risk $149 to win $100) in the latest Mariners vs. Cardinals odds, while the over/under, is 7.5. 

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The model has simulated Mariners vs. Cardinals 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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