Content on this page may include affiliate links. If you click and sign up/place a wager, we may receive compensation at no cost to you.
LSU travels to Lexington for a massive SEC showdown Saturday night when the Tigers take on Kentucky in a battle between two teams sitting at 4-1. The Tigers are coming off a dominant 63-14 blowout of McNeese in Week 5, with quarterback Sam Leavitt throwing three touchdown passes in the rout, and enter as 8.5-point road favorites. Kentucky (4-1) has been one of the SEC's best stories in 2026, going 4-1 on the strength of a strong home record and the steady play of quarterback Kenny Minchey. This is a pivotal conference game for both programs' SEC title hopes. Claim the latest Polymarket promo code SPORTSLINE to get a $25 trading bonus after a $10 deposit:
Kickoff is set for 7:00 p.m. ET at Kroger Field in Lexington, Ky. Kentucky are 8.5-point underdogs in the latest LSU vs. Kentucky odds, while the over/under is 50.5 points.
Before making any LSU vs. Kentucky picks, check out the college football predictions from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times. It entered Week 6 on a profitable 40-35 run on all top-rated college football picks! Anybody following could have seen strong returns!
The model has simulated LSU vs. Kentucky 10,000 times and the results are in. The model is going Under on the total, and it also says one side of the spread hits almost 60% of the time!
So who wins LSU vs. Kentucky, and which side of the spread hits almost 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is on a 40-35 run on top-rated CFB picks!
Don't miss out: All new SportsLine memberships include Paramount+ Premium -- a $13.99/month value -- for no extra cost! Join now and get it all.
GET VEGAS EXPERT PICKS FOR NFL, MLB, NBA, CBB, GOLF, NHL, HORSE RACING AND MORE - PLUS ADVANCED COMPUTER SIMULATIONS, WINNING TOOLS, AND MORE!
