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The high-scoring Ole Miss Rebels begin the post-Lane Kiffin era against the defense-minded Louisville Cardinals in a marquee college football Week 1 opener. Pete Golding, who led the Rebels to the semifinals of the College Football Playoff after Kiffin left for LSU, keeps the reins, as does QB Trinidad Chambliss, who was granted a sixth year of eligibility. Meanwhile, Louisville has won 9-10 games in all three seasons under Jeff Brohm. Ohio State transfer Lincoln Kienholz gets his first career start. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here:
Kickoff for the neutral-site game is set for 7:30 p.m. ET at Nissan Stadium in Nashville. The Rebels are 6.5-point favorites in the latest Louisville vs. Ole Miss odds, while the over/under is 55.5.
Before making any Louisville vs. Ole Miss picks, check out the college football predictions from expert Zack Cimini.
Cimini is a Las Vegas handicapper who's returned a profit across multiple sports. Over the past three college football seasons, Zack is 91-68-2, returning $1,420 to $100 bettors. He also enters the 2026 college football season on a 22-9 run (+1068) over his last 31 ATS picks. Anybody following him could have seen HUGE returns!
Now, Cimini has analyzed Louisville vs. Ole Miss from every angle and made his best bets.
We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.
So who wins Louisville vs. Ole Miss, and what critical x-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Louisville vs. Ole Miss spread to jump on, all from the expert on a 22-9 run (+1068) on college football picks!
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