The Louisville Cardinals (5-5, 3-4 ACC) secured their biggest win of the season against Syracuse last week. They'll visit the Duke Blue Devils at Wallace Wade Stadium (3-7, 0-6 ACC) in a conference matchup on Thursday. Kickoff is set for 7:30 p.m. ET.
The Cardinals are 20-point favorites in the latest Louisville vs. Duke odds from Caesars Sportsbook, while the over-under for total points scored is 60.5. (See the latest college football lines for all of this week's games on our college football odds page.)
Before you consider your Louisville vs. Duke picks or college football predictions, you need to see what the SportsLine Projection Model has to say.
The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 12 of the 2021 season on a 36-23 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.
The model knows Louisville's offense depends on Malik Cunningham. The dual-threat quarterback has thrown for 2,286 and 13 touchdowns with five interceptions. He also entered Week 12 ranked second in rushing touchdowns with 16. He leads the Cardinals in rushing yards (709) and could carve up a defense that's allowed at least 45 points in four consecutive contests.
The model also knows Duke relies on its ground attack. Only five FBS running backs have notched more carries than the Blue Devils' Mataeo Durant. He's racked up 1,095 rushing yards and nine rushing touchdowns on 220 touches.
Now the model has simulated Louisville vs. Duke 10,000 times, and the results are in. We can tell you that the model is leaning Under on the total, and it also says one side of the spread is hitting in almost 60 percent of simulations. You ABSOLUTELY need to see it before locking in your own picks.
Who wins the Louisville vs. Duke? And which side of the spread hits in almost 60 percent of simulations? ... Join SportsLine right now to see which side of the Louisville vs. Duke spread you need to jump on Thursday, all from the computer model on a 36-23 run on its top-rated college football side picks!
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