Lions vs. Colts prediction, line, odds: Expert releases his spread pick for 2026 NFL Week 3 preseason matchup

With jobs on the line, the Detroit Lions face the Indianapolis Colts as the 2026 NFL preseason schedule comes to a close on Saturday afternoon. Detroit has split a pair of preseason games and is coming off a 17-13 win over the Washington Commanders. Indianapolis, meanwhile, is still looking for its first win after a 13-13 tie with the New England Patriots in Week 1 and a 34-6 loss to the Atlanta Falcons a week ago. The Colts are expected to play their starters between eight to 12 snaps as Anthony Richardson starts at quarterback.