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Playoff contenders look to stay perfect on the season when the Detroit Lions battle the Buffalo Bills in a key interconference Week 2 matchup on Thursday Night Football. Detroit is coming off a 31-30 overtime win over the New Orleans Saints, while Buffalo held off the Houston Texans 36-31 on Sunday. The Lions are looking for their fifth consecutive winning season under coach Dan Campbell. The Bills, meanwhile, are looking to post their eighth winning season in a row and first under coach Joe Brady. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Kickoff is at 8:15 p.m. ET from New Highmark Stadium in Orchard Park, N.Y. The latest Lions vs. Bills odds have Buffalo as a 4.5-point favorite, while the over/under for total points scored is 53.5. The Bills are at -212 on the money line (risk $212 to win $100).
Before making any Lions vs. Bills picks, or Thursday Night Football predictions of your own, you NEED to see what SportsLine expert Larry Hartstein has to say.
A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus. Larry tied for 52nd place (out of 1,598 entries) in the 2022 Westgate Las Vegas SuperContest, going 53-34-3 ATS (61 percent). He is coming off a 2025 NFL season in which he went 50-37 ATS (57.5 percent), putting him at 643-555 ATS alltime. For NFL Office Pool players, Hartstein picked every game straight-up the past two seasons and nailed nearly 70 percent of those picks. He enters this season on a 22-11-1 roll on his last 34 picks involving the Lions, returning $966 to $100 players! Anyone following his picks could have seen huge returns.
Now, Hartstein has locked in another confident pick for Lions vs. Bills.
He's leaning Over the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.
So who wins Lions vs. Bills on Thursday night, and what x-factor makes one side of the spread hit HARD? ... Join SportsLine RIGHT NOW to see which side of the Lions vs. Bills line to back, all from the expert who has returned $966 to $100 players in his last 34 picks involving the Lions!
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Written by Daniel Kohn
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