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The Buffalo Bills and coach Joe Brady make their Highmark Stadium regular-season debut when they battle the NFC North-contending Detroit Lions. The Bills opened the season with an impressive 36-31 win over the Houston Texans in Week 1, while the Lions held off the New Orleans Saints 31-30 in overtime. Detroit (1-0), which finished fourth in the NFC North, was 9-8 in 2025. Buffalo (1-0), which was second in the AFC East, went 12-5. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Kickoff is set for 8:15 p.m. ET from Buffalo. The latest Lions vs. Bills odds have Buffalo as 4.5-point favorites, while the over/under for total points scored is 53.5. The Bills are at -224 on the money line (risk $224 to win $100).
Before making any Lions vs. Bills picks or 2026 NFL Week 2 predictions of your own, you NEED to see which side the proven SportsLine projection model is on.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2026 NFL season on a 53-39 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!
Now, the model has locked in another confident pick for Lions vs. Bills in the NFL Week 2 2026 matchup.
We can tell you it's leaning Over the point total. It also says that one side of the spread is hitting in over 50% of simulations! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.
So who wins Lions vs. Bills in the 2026 Week 2 matchup, and which side of the spread hits over 50% of the time? ... Join SportsLine RIGHT NOW to see which side of the Lions vs. Bills line to back, all from the model that is on a 53-39 run on top-rated picks since 2024!
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Written by Daniel Kohn
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