The Memphis Grizzlies host the Los Angeles Lakers on Wednesday night in an NBA Western Conference battle at the FedEx Forum in Memphis, Tenn. Tip-off is set for 8 p.m. ET. 

Memphis is a 5.5-point favorite in the latest Lakers vs. Grizzlies NBA odds from Caesars Sportsbook, while the Over-Under is set at 225.5 (see up-to-date odds for every game this week on our NBA odds page). 

Before you lock in any Grizzlies vs. Lakers picks, you NEED to check out the NBA predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model entered Week 11 of the 2021-22 NBA season on a stunning 48-24 roll on all top-rated NBA picks, returning almost $2,000. Anyone following it has seen HUGE returns.

The model knows the Grizzlies (21-14) come in off a big 114-113 victory against the Suns, who have the second-best record in the NBA. Ja Morant and Desmond Bane combined for 65 points in that game, and Steven Adams had 16 rebounds, nine on the offensive end. The Grizzlies score 111 points per game (sixth in the NBA) and are second in rebounding (47.3 per game) and first in offensive boards (13).   

The model also knows Los Angeles (17-18) still has plenty of talent. LeBron James scored at least 31 for the fifth straight game in a 132-123 win in Houston on Tuesday and averages more than 27 points. James and Russell Westbrook both had triple-doubles, and Carmelo Anthony (24 points) and usual reserve Malik Monk (25) also starred. The Grizzlies rank 18th in the league defensively, allowing 108.6 points per contest.

Now, the model has locked in on Grizzlies vs. Lakers, and the model is leaning Under the total. It also has an against-the-spread prediction that hits in well over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any NBA picks.

Who wins Lakers vs. Grizzlies on Wednesday? And which side of the spread hits in well over 50 percent of simulations? ... Join SportsLine right now to find out which side of the Grizzlies vs. Warriors spread you should be all over Wednesday, all from the model on a 48-24 run on NBA picks!