The Los Angeles Lakers and the Milwaukee Bucks square off in a cross-conference matchup at 7:30 p.m. ET on Wednesday. Milwaukee is favored by nine points at Caesars Sportsbook, while the Over-Under is set at 222 (see up-to-date odds for every game this week on our NBA odds page). Before making any Lakers vs. Bucks picks, you NEED to check out the NBA predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $9,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model enters Week 5 of the 2021-22 NBA season up over $900 on all top-rated NBA picks this season. It's also on a stunning 113-75 roll on top-rated NBA picks against the spread that dates back to last season. Anyone following it has seen HUGE returns.

The model knows the Lakers have high-end talent, even without LeBron James. Los Angeles will be led by Russell Westbrook and Anthony Davis, and Westbrook is putting up 19.4 points, 8.7 rebounds and 8.3 assists per game. Davis adds 24.2 points, 10.9 rebounds and 2.1 blocks per game along with elite-level defense. The Lakers are a top-10 team in the NBA in field goal shooting at 46.2 percent, and Los Angeles also lands in the top ten with 23.9 assists per game. Defensively, Los Angeles is tremendous at protecting the rim, including 6.1 blocked shots per game.

The model also knows the Bucks have the reigning NBA Finals MVP in Giannis Antetokounmpo. Antetokounmpo is averaging 26.5 points, 11.3 rebounds and 6.0 assists per game, and he remains a dynamic shot creator and elite defender. Milwaukee is No. 2 in the NBA in three-pointers, converting 14.6 per game, and the Bucks rank in the top ten in both three-point accuracy and turnovers. On defense, the Bucks have been elite for multiple seasons, and opponents are shooting just 33.1 percent from three-point range during the 2021-22 season.

Now, it has set its sights on Lakers vs. Bucks. We can tell you the model is leaning under the total, and it also says one side of the spread hits in well over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any NBA picks.

Who wins Lakers vs. Bucks? And which side of the spread hits in well over 50 percent of simulations? ... Join SportsLine right now to find out which side of the Lakers vs. Bucks spread you should be all over Wednesday, all from the model on a roll on NBA picks!