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No. 7 Ohio State bounced back from a heartbreaking 24-23 road loss at No. 4 Texas in Week 2 with a 59-3 blowout of Kent State last week behind junior quarterback Julian Sayin, and the Buckeyes (2-1) return home to Ohio Stadium on Saturday to face the Illinois Fighting Illini. The Fighting Illini come in at 2-1 as well, picking up their second win of the season with a 48-10 rout of Southern Illinois last week behind senior quarterback Katin Houser, who has put up good numbers through three games after a Week 2 loss to Duke. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Kickoff is set for noon ET at Ohio Stadium in Columbus, Ohio. The Buckeyes are 26.5-point favorites in the latest Illinois vs. Ohio State odds. The over/under for total points is 54.5.
Before making any Illinois vs. Ohio State picks, check out the college football predictions from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times. It is off to a profitable 22-19 start on all top-rated college football picks so far this season, and it has been upgraded for the 2026 season to better factor in the transfer portal!
The model has simulated Illinois vs. Ohio State 10,000 times and the results are in. The model is going Under on the total, and it also says one side of the spread hits more than 60% of simulations!
So who wins Illinois vs. Ohio State, and which side of the spread hits more than 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is on a 22-19 run on top-rated CFB picks!
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