Guardians vs. Tigers odds, line, prediction: 2026 MLB picks for Monday, May 18, from proven model

The surging Cleveland Guardians begin a three-game series with struggling Detroit Tigers in an AL Central showdown on Monday. The Guardians, who have won seven of 10, start Slade Cecconi (2-4, 5.60 ERA) while the Tigers counter with veteran southpaw Framber Valdez (2-2, 4.32). 

First pitch from Comerica Park in Detroit is set for 6:40 p.m. ET. Detroit is a -149 favorite on the money line (risk $149 to win $100) in the latest Guardians vs. Tigers odds, while the over/under is 8.5. 

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The model has simulated Guardians vs. Tigers 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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