Giants vs. Cubs odds, line, prediction: 2026 MLB picks for Friday, June 5 from proven model

The Chicago Cubs, fresh off a dramatic come-from-behind win over the Athletics on Thursday, host the San Francisco Giants for a Friday matinee to begin a three-game series. The Cubs (33-30) were down 6-1 in the eight before rattling off six runs for a walk-off win. The Giants (25-38), meanwhile, just took two of three from red-hot Milwaukee, including a 12-9 win Thursday. Robbie Ray (3-6, 4.45 ERA) takes the ball for San Francisco, countered by Chicago RHP Edward Cabrera (3-2, 4.00).

First pitch is set for 2:20 p.m. ET from Wrigley Field in Chicago. Chicago is a -162 favorite on the money line (risk $162 to win $100) in the latest Giants vs. Cubs odds, with San Francisco priced at +135 (risk $100 to win $135 in profit). The over/under for total runs is 11, one of the highest highest totals this season. 

Before making any Giants vs. Cubs picks, or MLB predictions, you NEED to see what the SportsLine Projection Model has to say.

SportsLine Projection Model simulates every MLB game 10,000 times and enters Week 11 of the MLB season on a red-hot 17-5 run (77%) on all top-rated MLB picks. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following could have seen strong returns!

The model has simulated Giants vs. Cubs 10,000 times and the results are in. The model is going Under on the total, and is also says one side of the money line has ALL the value!

Who wins Cubs vs. Giants, and which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the Giants vs. Cubs money line you should be all over, all from the model that enters Week 11 of the MLB season on a red-hot 17-5 run!