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The 14th-ranked USC Trojans look to make it two in a row to start the season when they battle the Fresno State Bulldogs in a Week 1 college football non-conference matchup on Friday night. Fresno State, now a member of the Pac-12, finished tied for fifth with Hawaii at 5-3 in the Mountain West and were 9-4 overall in 2025. USC, which tied for fourth in the Big Ten with Michigan at 7-2, were 9-4 overall a year ago. USC has won five of six all-time meetings, including a 45-17 win in 2022. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here:
Kickoff is set for 9 p.m. ET at Los Angeles Memorial Coliseum. The Trojans are 22.5-point favorites in the latest Fresno State vs. USC odds. The over/under for total points is 51.5.
Before making any Fresno State vs. USC picks, check out the college football predictions from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times. It is on a 32-19 run on top-rated college football money-line picks since the 2024 season, and it has been upgraded for the 2026 season to better factor in the transfer portal!
The model has simulated Fresno State vs. USC 10,000 times and the results are in. The model is going Under on the total, and it also says one side of the spread is the better value!
So who wins Fresno State vs. USC, and which side of the spread is the better value? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is on a 32-19 run on top-rated CFB picks!
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Written by Daniel Kohn
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