Content on this page may include affiliate links. If you click and sign up/place a wager, we may receive compensation at no cost to you.
A rare Week 1 conference battle takes place on Labor Day as the No. 19 SMU Mustangs visit the Florida State Seminoles. The Noles (1-0) kicked off their season with a Week 0 victory over New Mexico State after going 5-7 last season. The Mustangs (0-0) went 9-4 a year ago, which culminated in a victory in the Holiday Bowl. SMU won the lone meeting since it joined the ACC, which came back in 2024. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here:
Kickoff is at 7:30 p.m. ET from Doak Campbell Stadium in Tallahassee, Fla. The Mustangs are 2.5-point favorites in the latest SMU vs. Florida State odds, while the over/under is 53.5 points.
Before making any Florida State vs. SMU picks, check out the college football predictions from SportsLine expert Josh Nagel.
Nagel is a Reno-based analyst and radio host who has worked in the sports handicapping industry for more than 20 years. SportsLine's assistant managing editor has covered the wagering industry on a variety of platforms, and has won numerous sports handicapping contests. Nagel is also 8-3 (+485) over his last 11 college football picks involving SMU.
Now, Nagel has analyzed SMU vs. Florida State from every angle and made his picks. We can tell you he is leaning Under 53.5, and he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.
So who wins Florida State vs. SMU, and which side of the spread is a must-bet? Join SportsLine right now to see which side of the SMU vs. FSU spread you need to jump on, all from the college football expert who is 8-3 (+485) over his last 11 SMU picks!
Don't miss out: All new SportsLine memberships include Paramount+ Premium -- a $13.99/month value -- for no extra cost! Join now and get it all.
GET VEGAS EXPERT PICKS FOR NFL, MLB, NBA, CBB, GOLF, NHL, HORSE RACING AND MORE - PLUS ADVANCED COMPUTER SIMULATIONS, WINNING TOOLS, AND MORE!
Written by Ross Kelly
View expert profile
