Diamondbacks vs. Cubs odds, line, prediction: 2026 MLB picks for Friday, May 1, from proven model

The Chicago Cubs have won 12 out of 15 games and aim to keep the run going as they host the Arizona Diamondbacks to begin a weekend series Friday. The Cubs (19-12) won the final two games of their three-game set in San Diego, while the D'backs (16-14) went 1-2 in Milwaukee, allowing 13 runs in each defeat. The Cubs are 11-5 at Wrigley Field, the best home mark in the National League. 

First pitch from Wrigley Field in Chicago is set for 2:20 p.m. ET. The latest Diamondbacks vs. Cubs odds as Chicago at -136 won the money line (risk $136 to win $100), while the over/under is set at 7.5 runs. 

Before making any Cubs vs. Diamondbacks picks, or MLB predictions, you NEED to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It was a profitable 35-29 on top-rated MLB money-line picks last season. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following could have seen strong returns!

The model has simulated Diamondbacks vs. Cubs 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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