Two struggling National League Central rivals square off Monday as the Chicago Cubs visit the Cincinnati Reds for the opener of their four-game series. Chicago (16-24), which is 9.5 games out of first place in the division, ended its four-game losing streak with a 5-4 home triumph over Arizona on Sunday. Cincinnati (12-28) owns the worst record in the major leagues but is coming off a 3-2 victory at Toronto. First pitch at Great American Ball Park is set for 6:40 p.m. ET.

Chicago is listed as a -130 favorite (risk $130 to win $100) on the money line in the latest Cubs vs. Reds odds from Caesars Sportsbook, while the over-under for total runs scored is nine (see the latest lines for every game on our MLB odds page).

Before making any Reds vs. Cubs picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

The model simulates every MLB game 10,000 times and is off to a strong start to the 2022 season. It's on a 41-30 roll on top-rated MLB money-line picks through seven weeks, returning almost $600 for $100 players. Anyone following it has seen HUGE returns!

The model knows the Cubs have fared better on the road than at home this season as they are 9-9 away from Wrigley Field and went 4-2 on their most recent trip. Chicago relied on some late power on Sunday to emerge victorious after squandering an early 3-0 lead. Patrick Wisdom and Frank Schwindel went back-to-back for the second consecutive day, opening the eighth inning with blasts to help the Cubs finish 3-4 on their seven-game homestand.

The model also knows Great American Ball Park may seem a bit unfamiliar to Cincinnati, which has lost more games on the road (19) than it has even played at home (14). The Reds are one of the lowest-scoring teams in the National League, scoring more runs (155) than only Pittsburgh (133) and producing a total of five during their three-game series at Toronto over the weekend. Kyle Farmer has been one of Cincinnati's hottest contributors at the plate as he has gone 8-for-18 during his five-game hitting streak.

Now, it has set its sights on Cubs vs. Reds. We can tell you the model is projecting 9.5 total runs, and it also says one side of the money line has all the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Cubs vs. Reds? And which side of the money line has all the value? ... Join SportsLine right now to find out which side of the Reds vs. Cubs money line you should be all over on Monday, all from the model on a roll on MLB picks!