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Cubs vs. Marlins odds, line, start time, picks, best bets for May 20 matchup from proven model

SportsLine's projection model, which is on a 10-5 roll on top-rated MLB picks, has locked in its MLB picks for the Cubs vs. Marlins on Tuesday

By@SportsLinePublished: May 20, 2025 7:53PM UTC . 2 min read

The Miami Marlins (19-27) and the Chicago Cubs (28-20) are set to battle in Game 2 of their series on Tuesday. The Marlins took Game 1 over Chicago, notching an 8-7 victory over the Cubs. Ryan Weathers (1-0, 1.80 ERA) starts for Miami. Jameson Taillon (2-3, 4.53 ERA) gets the nod for Chicago. 

First pitch is scheduled for 6:40 p.m. ET at loanDepot Park in Miami. The Cubs are the -142 money-line favorites (bet $142 to win $100) in the latest Cubs vs. Marlins odds, while the Marlins are +119 underdogs (bet $100 to win $119). The Over/Under for total runs scored is 8.5 in the latest MLB odds. 

Before you make any Cubs vs. Mets picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 9 of the 2025 MLB season on a 13-8 run (62%) on top-rated MLB money-line picks. Anybody following could have seen strong returns!

The model has simulated Cubs vs. Marlins 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

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