Commanders vs. Lions odds, line: 2025 NFL Playoffs picks, NFC Divisional Round predictions from proven computer model

The Detroit Lions will begin their quest to reach their first-ever Super Bowl when they take on the upstart Washington Commanders in an NFC Divisional Round matchup on Saturday. Washington is coming off a last-second 23-20 win over the Tampa Bay Buccaneers in the Wild Card Round, while Detroit had the NFC's lone bye. The Commanders (12-5), second in the NFC East, have won five in a row and are 5-3 on the road. The Lions (15-2), who won the NFC North for the second consecutive season, are 7-2 at home.

Kickoff from Ford Field in Detroit is set for 8 p.m. ET. The Lions are 9.5-point favorites in the latest Commanders vs. Lions odds, while the over-under for total points scored is 55.5. The Lions are -503 money-line favorites (risk $503 to win $100), while the Commanders are +378 underdogs (risk $100 to win $378). Before entering any Commanders vs. Lions picks, you NEED to see the NFL playoff predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the Divisional Round of the 2025 NFL playoffs on a 31-15 betting hot streak on top-rated NFL picks this year -- a stunning 67% success rate. Longer term, it is on a 211-143 roll on top-rated NFL picks that dates back to the 2017 season and a 65-36 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following could have seen HUGE returns!

The model has simulated Commanders vs. Lions 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that hits in well over 50% of simulations!

So who wins Commanders vs. Lions on Saturday in the 2025 NFL playoffs? And which side of the spread cashes in well over 50% of simulations? ... Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks!