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The San Francisco 49ers will look to stay perfect on the year when they take on the Washington Commanders in a key NFC matchup on 'Monday Night Football.' San Francisco defeated Seattle 32-29 in Week 5, while Washington tied the New York Giants 27-27. The Commanders (1-3-1), who are fourth in the NFC East, are 0-2 on the road this season. The 49ers (5-0), who have outscored their opponents 154-93, are 3-0 on their home field in 2026. San Francisco linebacker Dre Greenlaw has been suspended and will miss the game. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Kickoff is set for 8:15 p.m. ET from Levi's Stadium in Santa Clara, Calif. The latest Commanders vs. 49ers odds have San Francisco as 7.5-point favorites. The over/under for total points scored is 50.5. The 49ers lead the all-time series 23-12-1, winning three of the last four.
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The model, which simulates every NFL game 10,000 times, is up more than $5,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 6 of the 2026 NFL season on a 57-46 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!
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Written by Daniel Kohn
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