Teams looking to get into the win column in Big 12 play meet when the Colorado Buffaloes take on the TCU Horned Frogs on Saturday. Colorado is coming off a 24-21 loss to BYU, while TCU fell 27-24 at Arizona State in Week 5. The Buffaloes (2-3, 0-2 Big 12), who have lost two of three, are 0-1 on the road this season. The Horned Frogs (3-1, 0-1 Big 12), who are looking to avoid a 0-2 start to conference play for the first time since 2013, are 2-0 on their home field in 2025.

Kickoff from Amon G. Carter Stadium in Fort Worth, Texas, is at 7:30 p.m. ET. The all-time series is tied 1-1. The Horned Frogs are 13.5-point favorites in the latest Colorado vs. TCU odds, while the over/under for total points scored is 57.5 via SportsLine consensus. 

Before making any Colorado vs. TCU picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 37-24 combined on money-line and over/under picks since the beginning of 2024. Anyone following at sportsbooks and on betting apps could have seen STRONG returns!

The model has simulated Colorado vs. TCU 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Colorado vs. TCU, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!