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The Week 4 college football schedule features at least one game on Thursday, Friday and Saturday. In perhaps the most intriguing matchup, Arch Manning goes to Knoxville for the first meeting between Texas and Tennessee as SEC foes at noon ET on Saturday. The top-rated Longhorns are 3.5-point road favorites against the No. 14 Vols.
Other Week 4 college football lines of note include Georgia (-14) against Oklahoma, Michigan (-4.5) against Iowa, LSU (-9.5) vs. Texas A&M and Oregon (-3) against USC. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Our proven computer model has revealed exact score predictions for each game that can help you formulate spread, money-line and over/under under picks.
Before making any college football picks for those games or others in Week 4, be sure to see them all.
The model simulates every FBS game 10,000 times. It is on a 22-19 run on all top-rated college football picks this season, and it has been upgraded for the 2026 season to even better factor in the transfer portal!
Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 4 game, and the exact score projections are in.
One of the score projections from the model in Week 4: Georgia beats Oklahoma 28-19, making the Sooners (+14) the value pick against the spread, while the Over 43.5 also hits.
The model has also made the exact call on the score for every other game, and it's calling for multiple underdogs to win outright, including an upset in one of the week's biggest matchups!
So what is the exact score prediction for each Week 4 game, and which underdog pulls off a shocking upset? ... Join SportsLine now to see who wins and covers every single game, all from the model that is on a 22-19 run on top-rated CFB this season!
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