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College football's first full weekend of action kicks off on Thursday, Sept. 3, and runs all the way through Labor Day Monday. There's at least one FBS matchup on each day over the holiday weekend, and matchups such as LSU vs. Clemson, Notre Dame vs. Wisconsin, Ole Miss vs. Louisville and Florida State vs. SMU anchor the action. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here:
Our proven computer model has revealed exact score predictions for each game that can help you formulate spread, money-line and over/under under picks.
Before making any college football picks for those games or others in Week 1, be sure to see them all.
The model simulates every FBS game 10,000 times. It is on a 32-19 run on top-rated CFB money-line picks since the 2024 season, and it has been upgraded for the 2026 season to even better factor in the transfer portal!
Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 1 game, and the exact score projections are in.
One of the score projections from the model in Week 1: Penn State beats Marshall 39-11 in Matt Campbell's debut with the Nittany Lions. That score makes Penn State (-24.5) the value against the spread and the Under (52.5) the side to play for the total.
The model has also made the exact call on the score for every other game, and it's calling for an underdog to win outright in Week 1!
So what is the exact score prediction for each Week 1 game, and which underdog starts the season off with a shocking upset? ... Join SportsLine now to see who wins and covers every single game, all from the model that is on a 32-19 run on top-rated money line picks since 2024!
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