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The Week 5 college football odds aren't showing much love to 14th-ranked Iowa. Despite being undefeated and at home, the Hawkeyes are 14-point underdogs to No. 5 Ohio State, per the latest college football lines. That's one of three ranked matchups on Saturday, with the others taking place in the SEC. No. 7 Alabama is favored by 6 points over No. 16 Mississippi State, per the Week 5 college football spreads, while No. 8 Florida is a 4-point road favorite at 25th-ranked Missouri. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Other games to make Week 5 college football picks on include Notre Dame vs. North Carolina (+21.5), Tennessee vs. Auburn (+7.5) and Miami vs. Clemson (+17.5). No game has a higher over/under than Louisville visiting NC State, which has a total of 60.5.
Before making any college football picks for those games or others in Week 5, be sure to see what the SportsLine Projection Model has to say.
The model simulates every FBS game 10,000 times. It enters Week 5 on a 32-24 run on all top-rated college football picks, returning nearly $600 for $100 players. Anybody following could have seen HUGE returns!
Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 5 game, and the results are in.
One of the college picks the model is high on during Week 5: Navy (+2.5, 47.5) covers versus Air Force in a noon ET kickoff. The Midshipmen cover in over 60% of simulations. Another prediction: No. 25 Missouri (+4, 56.5) covers at home versus No. 8 Florida at 3:30 p.m. ET in well over 50% of simulations. The Under also hits well over 50% of the time in an A-rated pick.
The model has also made the call on who wins and covers in every FBS matchup, including an underdog of nearly a touchdown who outright wins in one of the week's biggest games!
So which college football teams should you back in Week 5, and which underdog of nearly a touchdown pulls off a massive upset? ... Join SportsLine now to see who wins and covers every single game, all from the model that is on a 32-24 run on top-rated picks!
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Written by Ross Kelly
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