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The Week 4 college football schedule is when conference play officially kicks off for many teams. The Big Ten features the likes of USC vs. Oregon (-2.5) and Michigan vs. Iowa (+4.5) to make Week 4 college football picks on, with the SEC offering Georgia vs. Oklahoma (+14) and Texas vs. Tennessee (+4.5). Elsewhere, Notre Dame vs. Purdue (+27.5) is always a hotly contested in-state rivalry as the two Battle for the Shillelagh Trophy in their 90th all-time meeting. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Other games to make Week 4 college football picks on include Ohio State vs. Illinois (+27.5), Ole Miss vs. Florida (-3.5) and LSU vs. Texas A&M (+9.5). One of the slimmest Week 4 college football spreads has UCLA as 1.5-point favorites as it makes the cross-country trip to take on Maryland.
Before making any college football picks for those games or others in Week 4, be sure to see what the SportsLine Projection Model has to say.
The model simulates every FBS game 10,000 times. It is off to a profitable 22-19 start on all top-rated college football picks so far this season, and it has been upgraded for the 2026 season to better factor in the transfer portal!
Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 4 game, and the results are in.
One of the college picks the model is high on during Week 4: Colorado (+9.5, 54.5) covers at Baylor in a noon ET kickoff. The Buffs cover in well over 50% of simulations. Another prediction: USC (+2.5, 62.5) covers at home versus Oregon at 7:30 p.m. ET in almost 60% of simulations in an A-rated pick. The Under also connect over 60% of the time.
The model has also made the call on who wins and covers in every FBS matchup, including a top-5 ranked team which outright loses in one of the week's biggest games!
So which college football teams should you back in Week 4, and which top-5 team goes down hard? ... Join SportsLine now to see who wins and covers every single game, all from the model that is on a profitable 22-19 run on top-rated picks so far this season!
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Written by Ross Kelly
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