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All eyes will be on Oxford, Miss., during the Week 3 college football schedule as Lane Kiffin returns to The Grove. His former team in Ole Miss will host Kiffin's new squad in LSU, as the Tigers are 3-point road favorites per the Week 3 college football odds. This is the lone top 10 matchup one can make college football bets on this week, and each of their last six meetings have been won by the home team. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Other games to make Week 3 college football picks on include ones in which several teams begin conference play. There's Georgia vs. Arkansas (+25), USC vs. Rutgers (+24.5) and North Carolina vs. Clemson (-3). Additionally, the new No. 1 in the Texas Longhorns will host an in-state foe as Arch Manning and co. take on UTSA (+30).
Before making any college football picks for those games or others in Week 3, be sure to see what the SportsLine Projection Model has to say.
The model simulates every FBS game 10,000 times. It is on a 33-21 run on top-rated CFB money-line picks since the 2024 season, and it has been upgraded for the 2026 season to even better factor in the transfer portal!
Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 3 game, and the results are in.
One of the college picks the model is high on during Week 3: South Carolina (-3.5, 58.5) covers at home versus Mississippi State at 4:15 p.m. ET. The Gamecocks cover in nearly 60% simulations, and the Under hits over 50% of the time. Another prediction: Notre Dame (-29.5, 52.5) covers the massive line versus Michigan State at 7:30 p.m. ET in almost 60% of simulations.
The model has also made the call on who wins and covers in every FBS matchup, including an underdog of nearly a touchdown who wins outright in one of the week's biggest games!
So which college football teams should you back in Week 3, and which underdog pulls off a shocking upset? ... Join SportsLine now to see who wins and covers every single game, all from the model that is on a 33-21 run on top-rated money line picks since 2024!
Don't miss out: All new SportsLine memberships include Paramount+ Premium -- a $13.99/month value -- for no extra cost! Join now and get it all.
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Written by Ross Kelly
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