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A pair of potential CFP previews featuring four Blue Blood programs highlight the contests to make Week 2 college football picks on. In one, Ohio State vs. Texas has the No. 5 Longhorns as 1.5-point home favorites over the top-ranked Buckeyes, per the Week 2 college football odds. Additionally, these two programs' bitter rivals will face off as well as Michigan vs. Oklahoma takes place at The Big House with the Sooners 5.5-point road favorites. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here:
Elsewhere on the Week 2 college football schedule are several in-state matchups such as LSU vs. Louisiana Tech (+34.5), Penn State vs. Temple (+23.5) and the Cy-Hawk Trophy being up for grabs in Iowa vs. Iowa State (+14). One of the biggest college football spreads has Ole Mis, coming off a short week, as 47.5-point favorites over Charlotte.
Before making any college football picks for those games or others in Week 2, be sure to see what the SportsLine Projection Model has to say.
The model simulates every FBS game 10,000 times. It is on a 33-20 run on top-rated CFB money-line picks since the 2024 season, and it has been upgraded for the 2026 season to even better factor in the transfer portal!
Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 2 game, and the results are in.
One of the college picks the model is high on during Week 2: Kentucky (+10, 49.5) covers against Alabama in a 3:30 p.m. ET kickoff well over 60% of the time. Another prediction: Iowa State (+14, 41.5) covers at Iowa at 7:30 p.m. ET. The Cyclones cover in well over 50% simulations, and the Over hits more than 50% of the time.
The model has also made the call on who wins and covers in every FBS matchup, including a double-digit underdog who outright wins!
So which college football teams should you back in Week 2, and which underdog pulls off a shocking upset? ... Join SportsLine now to see who wins and covers every single game, all from the model that is on a 33-20 run on top-rated money line picks since 2024!
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Written by Ross Kelly
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