The Week 3 college football schedule runs Thursday through Saturday, and after a bit of a slower slate in Week 2, this Saturday brings some huge matchups. Perhaps the biggest is the top-15 showdown between Georgia and Tennessee in Knoxville, Tenn. After opening as around a touchdown favorite, Georgia is now just -4 on the road. Elsewhere, Notre Dame is -6.5 against Texas A&M, LSU is -7 versus Florida, and South Carolina is -3 versus Vanderbilt.

Before making any Week 3 college football predictions, be sure to check out the Week 3 college football picks from our proven CFB expert Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. After opening this season 5-3, he's now on an 18-9 roll in his SportsLine best bets column dating back to last season!

Now, he's turned his attention to the 2025 Week 3 college football odds (see the latest college football lines for each game this week on our college football odds page) and is revealing his top plays.

For Week 3, Casale is backing Miami (-17.5) against South Florida as the Hurricanes look to slow the hard-charging Bulls, who have opened the season with big upsets against Boise State and Florida.

"The issue the Bulls face on Saturday is while Boise State and Florida are good teams, Miami is miles better in the trenches," Casale said. "The Hurricanes have one of the country's top offensive and defensive lines. We saw that in the opener when the Hurricanes pushed a good Notre Dame defense around and gave up just 93 yards rushing."

Casale has also found another college football picks he loves, backing an underdog in a game where he says the wrong team is favored! You ABSOLUTELY need to see what he's playing before locking in any college football picks.

What are Casale's best bets for Week 3 in the 2025 college football season, and which lines should you jump on now? ... Join SportsLine right now to see Thomas Casale's best bets, all from one of the top college football handicappers in the nation who is on a 18-9 roll on his best bets!