Week 2 of the NFL preseason kicks off on Thursday with a pair of game, and the nightcap has the San Francisco 49ers visiting the Los Angeles Chargers. Both QB1s sat last week as backups like Trey Lance, DJ Uiagalelei and Adrian Martinez got lots of work as L.A. defeated Houston in the opener, while San Fran fell to Tennessee. The Niners defeated the Chargers, 30-23 at home, in last year's NFL preseason action as these two will meet for the 10th time in the preseason since 2014.
Kickoff is set for 10 p.m. ET from SoFi Stadium in Inglewood, Calif. The latest 49ers vs. Chargers odds have Los Angeles as a 1.5-point favorites, while the over/under for total points scored is 38.5.
Before making any Chargers vs. 49ers picks or 2026 NFL preseason predictions of your own, be sure to see what NFL expert Jeff Hochman has to say.
Jeff Hochman emerged on the sports betting scene in the 1990s. Today he's one of the nation's most respected and selective handicappers. He's 99-88-3 (+686) over the past five NFL seasons. Anybody following has seen strong returns.
Now, Hochman has zeroed in on 49ers vs. Chargers. We can tell you he's leaning Under the point total (39), and he's found a critical x-factor that has him jumping all over one side of the spread! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.
So who wins Chargers vs. 49ers in Week 2 of NFL preseason, and which side is he all over? ... Join SportsLine RIGHT NOW to see which side of the 49ers vs. Chargers line to back, all from one of SportsLine's premier NFL experts!
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Written by Ross Kelly
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