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Celtics vs. Knicks odds, line: Proven model reveals picks for NBA playoff matchup on May 16, 2025

The SportsLine Projection Model, up well over $10,000 on NBA picks over the past six seasons, has locked in its best bets for Game 6 of the Boston Celtics vs. New York Knicks in the 2025 NBA playoffs on Friday. Boston will be without Jayson Tatum (Achilles)

ByPublished: May 16, 2025 10:14PM UTC . 3 min read

The second-seeded Boston Celtics will look to even their best-of-seven Eastern Conference semifinal series with the third-seeded New York Knicks when they meet in Game 6 on Friday night. Boston avoided elimination with a 127-102 win in Game 5 as both of the Celtics' win in this 2025 NBA playoffs series have come by at least 22 points. The Celtics (61-21), the defending NBA champions, are looking to reach the East Finals for the fourth consecutive year. The Knicks (51-31), who are looking to reach the conference finals for the first time since 1999-00, have lost in the Eastern Conference semifinals in each of the past two seasons. Precious Achiuwa (ankle) is listed as questionable for the Knicks.

Tipoff from Madison Square Garden in New York is set for 8 p.m. ET. The Knicks are 2.5-point favorites in the latest Celtics vs. Knicks odds, while the over/under for total points scored is 211.5, which is a 2-point increase from opening at 209.5. The Knicks are -144 on the money line (risk $144 to win $100), while the Celtics are +122 (risk $100 to win $122).

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Before making any Celtics vs. Knicks picks, you NEED to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters the second week of the conference semifinals of the 2025 NBA playoffs on a sizzling 159-117 roll on all top-rated NBA picks, returning nearly $4,000. It is also 23-11 (68%) on top-rated NBA against-the-spread picks this season. Anyone following could have seen HUGE returns!

The model has simulated Celtics vs. Knicks 10,000 times and the results are in. We can tell you that the model is going Under on the point total, and it also says one side of the spread is hitting in well over 50% of simulations!

Who wins Celtics vs. Knicks, and which side of the spread cashes in well over 50% of simulations? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model on a 159-117 roll on top-rated NBA picks!

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Daniel Kohn

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