Cavaliers vs. Pistons odds, line: Proven model reveals picks for NBA Eastern Conference semifinal Game 1 matchup on Tuesday, May 5

The Detroit Pistons and Cleveland Cavaliers each escaped out of the first round of the NBA playoffs, winning a deciding Game 7 over the weekend. Now they face off on Tuesday in the second round of the Eastern Conference Playoffs. These teams split the four-game season series, with each going 1-1 on their home court. 

Tipoff from Little Caesars Arena in Detroit is set for 7 p.m. ET as the Pistons, No. 1 seed in the East, aim to defend the homecourt advantage. Detroit is at -3.5 in the latest Cavaliers vs. Pistons odds from FanDuel Sportsbook, while the over/under for total points scored is 215.5. 

Before making any Pistons vs. Cavaliers picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model entered the second round of the 2026 NBA playoffs on a sizzling 26-9 roll (74%) on top-rated NBA spread picks this season. Anyone following could have seen HUGE returns!

The model has simulated Cavaliers vs. Pistons 10,000 times and the results are in. The model is going Under on the point total, and it also says one side of the spread hits nearly 60% of the time!

Who wins Pistons vs. Cavaliers, and which side of the spread hits nearly 60% of the time? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model on a 26-9 roll on top-rated NBA picks!