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Teams with high powered offenses and elite quarterback play clash when the Buffalo Bills meet the Los Angeles Rams on 'Monday Night Football.' Buffalo is looking to rebound from last week's 29-26 loss to the New England Patriots, while Los Angeles downed Philadelphia 24-20. The Bills (3-1), who lead the AFC East, are outscoring their opponents 127-107 on the year. The Rams (2-2), who are third in the NFC West, have outscored their foes 85-83 this season. Buffalo holds a 9-6 edge in the all-time series, including wins in three of their last four. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Kickoff is at 8:15 p.m. ET from SoFi Stadium in Inglewood, Calif. The latest Bills vs. Rams odds have Los Angeles as a 3-point favorite, while the over/under for total points scored is 54.5. The Bills are 3-1 ATS in 2026, while the Rams are 2-2.
Before making any Bills vs. Rams picks, or 'Monday Night Football' predictions of your own, you NEED to see what SportsLine expert Larry Hartstein has to say.
A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus. He is coming off a 2025 NFL season in which he went 50-37 ATS (57.5 percent), putting him at 643-555 ATS all time. For NFL Office Pool players, Hartstein picked every game straight-up the past two seasons and nailed nearly 70 percent of those picks. He enters this season on a 28-10 roll on his last 38 picks involving the Rams, returning $1,701 to $100 players! Anyone following his picks could have seen huge returns.
Now, Hartstein has locked in another confident pick for Bills vs. Rams.
He's leaning Over the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.
So who wins Bills vs. Rams on Monday night, and what x-factor makes one side of the spread hit HARD? ... Join SportsLine RIGHT NOW to see which side of the Bills vs. Rams line to back, all from the expert who has returned $1,701 to $100 players in his last 38 picks involving the Rams!
Don't miss out: All new SportsLine memberships include Paramount+ Premium -- a $13.99/month value -- for no extra cost! Join now and get it all.
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Written by Daniel Kohn
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