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In a possible Super Bowl preview, the Buffalo Bills clash with the Los Angeles Rams on Monday Night Football. Buffalo is coming off a 29-26 loss to the New England Patriots in Week 4, while Los Angeles defeated the Philadelphia Eagles 24-20. The Bills (3-1), who lead the AFC East, are 1-0 on the road this season. The Rams (2-2), who are third in the NFC West, are just 1-1 as the home team in 2026. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Kickoff is set for 8:15 p.m. ET from SoFi Stadium in Inglewood, Calif. The latest Bills vs. Rams odds have Los Angeles as 2.5-point favorites. The over/under for total points scored is 54.5.
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Now, the model has locked in another confident pick for Bills vs. Rams in the NFL Week 5 2026 matchup.
We can tell you it's leaning Under the point total. It also says that one side of the spread hits in well over 50% of simulations! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.
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Written by Daniel Kohn
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