The 2022 NFL Thanksgiving Day schedule begins with a cross-conference matchup between the Buffalo Bills (7-3) and Detroit Lions (4-6) on Paramount+. Detroit has won three in a row while the Bills are coming off a Week 11 victory over the Browns in a game played in Detroit due to weather concerns. Kickoff for Thursday's game at Ford Field is set for 12:30 p.m. ET. Buffalo is favored by 9.5 points in the latest Lions vs. Bills odds from Caesars Sportsbook, and the over/under is 54.5.

Sunday's showdown will be televised on CBS and streamed live on Paramount+ with their MUST-HAVE Premium plan. Plus, you can watch games on ANY device and get 50% off one year of the Paramount+ Essential or Premium plan with code ALLYEAR by signing up here (expires 12/31/22)!

You can catch all your local NFL on CBS games on Paramount+, which now has two plans. The Essential Plan costs $4.99 per month to access Paramount's catalog of movies and TV shows with limited advertisements, plus your live local NFL games, international soccer and more. The Premium Plan is $9.99 per month and you can watch your local CBS live stream with no ads, on demand and the ability to download episodes for offline viewing. You can now get 50% off one year of the Paramount+ Essential or Premium plan with code ALLYEAR. It's valid until 12/31, so sign up now here.

Before you make any Bills vs. Lions picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 of the 2022 NFL season on an incredible 155-109 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

Now, it has simulated Lions vs. Bills 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread cashes in well over 50% of simulations! Don't forget, you may be able to stream the game here.

Who wins Bills vs. Lions on NFL Thanksgiving Day 2022? And which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks!