Astros vs. Tigers odds, line, prediction: 2026 MLB picks for Friday, June 26, from proven model

The Houston Astros will look to extend their winning streak to four games in a row when they battle the Detroit Tigers in a key American League matchup on Friday night. Houston defeated Detroit 2-1 on Thursday in the first of a four-game series. The Astros (40-43), who are second in the AL West, are 20-22 on the road this season. The Tigers (34-47), who have dropped three in a row, are 22-19 on their home field in 2026.

First pitch from Comerica Park in Detroit is set for 6:40 p.m. ET. Detroit is a -118 favorite on the money line (risk $118 to win $100) in the latest Astros vs. Tigers odds, while the over/under, is 9.

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