Angels vs. Guardians odds, line, prediction: 2026 MLB picks for Monday, May 11, from proven model

Two teams licking their wounds after series defeats over the weekend face off in a new set starting Monday, as the Cleveland Guardians host the Los Angeles Angels. Left-hander Joey Cantillo (2-1, 3.43 ERA) gets the ball for Cleveland, which lost two of three to the Twins but leads the AL Central at 21-21. Alek Manoah is expected to follow the opener in his second appearance of the season for the Angels, who dropped two at Toronto before winning 6-1 on Sunday. 

First pitch from Progressive Field in Cleveland is set for 6:10 p.m. ET. Cleveland is a -175 favorite on the money line (risk $175 to win $100) in the latest Angels vs. Guardians odds, while the over/under is 7.5. 

Before making any Angels vs. Guardians picks, or MLB predictions, you NEED to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times, and is coming off a 5-0 week on top-rated MLB picks. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following its MLB betting picks at sportsbooks and on betting sites could have seen strong returns.   

The model has simulated Angels vs. Guardians 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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