76ers vs. Knicks odds, line: Proven model reveals picks for NBA Opening Night 2026
The SportsLine Projection Model, up nearly $19,000 on top-rated NBA picks since 2018, has locked in its best bets for 76ers vs. Knicks on 2026 Opening Night


The defending NBA champion New York Knicks battle LeBron James and the Philadelphia 76ers as they help tip off the 2026-27 NBA season with Opening Night on Tuesday. Philadelphia finished last season at 45-37, while New York was 53-29. The 76ers, who were swept by the Knicks in the Eastern Conference semifinals, were 22-19 on the road last season. The Knicks, who won their first NBA championship since 1972-73, were 30-10 on their home floor in 2025-26. Philadelphia revamped its roster over the offseason. Besides signing James, among their key moves was aquiring Jaylen Brown from the Celtics for Paul George and several draft picks.
Tipoff from Madison Square Garden in New York is set for 7 p.m. ET. New York is a 4.5-point favorite in the latest 76ers vs. Knicks odds, while the over/under is 231.5.
Before making any 76ers vs. Knicks picks, you NEED to see what the SportsLine Projection Model has to say.
The SportsLine Projection Model simulates every NBA game 10,000 times and has returned nearly $19,000 in profit for $100 players on its top-rated NBA picks since 2018, including five straight seasons of four-digit profit. The model enters the 2026-27 season off yet another huge season, including going 26-10 (72%) on top-rated NBA spread picks. Anyone following could have seen HUGE returns!
The model has simulated 76ers vs. Knicks 10,000 times and the results are in. The model is going Under on the point total, and it also says one side of the spread hits well over 50% of the time!
Who wins 76ers vs. Knicks, and which side of the spread hits well over 50% time? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model that has returned nearly $19,000 on top-rated NBA picks!
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Written by Daniel Kohn
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