76ers vs. Knicks odds, line: Proven model reveals picks for NBA Eastern Conference semifinal Game 2 matchup on Wednesday, May 6

Historic rivals start another chapter in their story when Joel Embiid and the Philadelphia 76ers take on Jalen Brunson and the New York Knicks in the second round of the 2026 NBA Playoffs. The Knicks rolled the Sixers 137-98 in Game 1; Game 2 is Wednesday night at Madison Square Garden. The teams split the four regular-season meetings, each going 2-0 on the home court. 

Tipoff from Madison Square Garden in Manhattan is set for 7 p.m. ET as the Knicks, No. 3 seed in the East, aim to defend the homecourt advantage vs. the No. 7 Sixers. New York at -6.5 in the latest 76ers vs. Knicks odds from FanDuel Sportsbook, while the over/under for total points scored is 215.5. 

Before making any Knicks vs. 76ers picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model entered the second round of the 2026 NBA playoffs on a sizzling 26-9 roll (74%) on top-rated NBA spread picks this season. Anyone following could have seen HUGE returns!

The model has simulated 76ers vs. Knicks 10,000 times and the results are in. The model is going Over on the point total, and it also says one side of the spread hits well over 60% of the time!

Who wins Knicks vs. 76ers, and which side of the spread hits well over 60% of the time? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model on a 26-9 roll on top-rated NBA picks!