76ers vs. Celtics odds, line: Proven model reveals picks for NBA first round Game 5 matchup on Tuesday, April 28

The second-seeded Boston Celtics look to close out their best-of-seven series when they face the seventh-seeded Philadelphia 76ers in Game 5 of their Eastern Conference first-round playoff matchup on Tuesday. Boston grabbed a 3-1 series lead with a 128-96 win at Philadelphia on Sunday. The 76ers (45-37), who have not advanced past the first round since 2022-23, are 23-20 on the road this season. The Celtics (56-26), who have advanced to the second round in each of the last four seasons, are 31-12 on their home court in 2025-26.

Tip-off from TD Garden in Boston is set for 7 p.m. ET. The Celtics lead the all-time postseason series 69-51, and have won five of the past six playoff meetings. The Celtics are an 11.5-point favorite in the latest 76ers vs. Celtics odds from FanDuel Sportsbook, while the over/under for total points scored is 214.5. 

Before making any 76ers vs. Celtics picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model entered the second full week of the 2026 NBA playoffs on a sizzling 25-9 roll (74%) on top-rated NBA spread picks this season. Anyone following could have seen HUGE returns!

The model has simulated 76ers vs. Celtics 10,000 times and the results are in. The model is going Under on the point total, and it also says one side of the spread hits nearly 60% of the time!

Who wins 76ers vs. Celtics, and which side of the spread hits nearly 60% of the time? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model on a 25-9 roll on top-rated NBA picks!