76ers vs. Celtics odds, line: Proven model reveals picks for NBA first round Game 1 matchup on Sunday, April 19

The Boston Celtics look to win their second NBA championship in three years as they open up the playoffs against the Philadelphia 76ers in Game 1 of their first round series on Sunday. Philadelphia is coming off a 109-97 play-in game win over Orlando on Wednesday, while Boston defeated the Magic 113-108 on Sunday. The 76ers (45-37), the seventh seed in the East, are 22-19 on the road this season. The Celtics (56-26), the second seed, are 30-11 on their home court. Philadelphia is expected to be without Joel Embiid (appendectomy).

Tip-off from TD Garden in Boston is set for 1 p.m. ET. The Celtics lead the all-time series 275-200, but the teams split four meetings this season. The Celtics are a 12.5-point favorite in the latest 76ers vs. Celtics odds, while the over/under for total points scored is 213.5. 

Before making any 76ers vs. Celtics picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model entered the 2026 NBA playoffs on a sizzling 23-9 roll (72%) on top-rated NBA spread picks this season. Anyone following could have seen HUGE returns!

The model has simulated 76ers vs. Celtics 10,000 times and the results are in. The model is going Under on the point total, and it also says one side of the spread hits nearly 60% of the time!

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