49ers vs. Saints prediction, odds, line, spread: Proven model reveals NFL picks, best bets for Week 12, 2022
The Week 12 NFL schedule features a battle between teams that have been in the upper echelon of the NFC for several years when Andy Dalton and the New Orleans Saints (4-7) head west to take on Jimmy Garoppolo and the San Francisco 49ers (6-4). The Saints are coming off an impressive 27-20 win over the defending Super Bowl champion Los Angeles Rams, while the 49ers are looking to build off their 38-10 blowout win over the Arizona Cardinals on Monday Night Football in Mexico City. New Orleans is 4-7 against the spread and San Francisco is 5-5 ATS in 2022.
Kickoff is at 4:25 p.m. ET. San Francisco is favored by 9 points in the latest 49ers vs. Saints odds from Caesars Sportsbook, and the over/under is set at 43.5 points. Before making any Saints vs. 49ers picks or predictions, you'll want to see what the SportsLine Projection Model is saying.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 of the 2022 NFL season on an incredible 155-109 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.
Now, it has simulated 49ers vs. Saints 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it also says one side of the spread hits well over 50% of the time. You absolutely need to see it before locking in your own picks.
So who wins 49ers vs. Saints? And which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.
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