Week 2 of the 2023 NFL season features a matchup of victorious NFC West rivals from Week 1, the Los Angeles Rams and the San Francisco 49ers. The Rams surprisingly won at Seattle, 30-13, while the 49ers defeated Pittsburgh, 30-7. Last season, San Francisco swept both meetings, 24-9 in the Bay Area and 31-14 in Los Angeles.

Kickoff from SoFi Stadium in Los Angeles is scheduled for 4:05 p.m. ET. San Francisco is a 7.5-point favorite and the over/under for total points scored is 45 points in the latest 49ers vs. Rams odds.

Before making any 49ers vs. Rams picks of your own, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2023 NFL season on an incredible 163-114 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 17-7 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

Now, the model has set its sights on 49ers vs. Rams. We can tell you the model is leaning Under on the point total, and it also says one side of the spread cashes in well over 50% of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

Who wins 49ers vs. Rams in Week 2 of the 2023 NFL season, and which side of the spread cashes well over 50% of the time? Join SportsLine right now to find out which side of the 49ers vs. Rams spread is a MUST-BACK, all from the model on a 163-114 roll on NFL picks!