Content on this page may include affiliate links. If you click and sign up/place a wager, we may receive compensation at no cost to you.
The third week of the 2026 NFL season features 14 Sunday matchups, and NFL bettors are looking for score predictions they can work off of to form spread, total, money-line and prop picks ahead of a massive Week 3 slate. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Some notable NFL spreads on the Week 3 NFL schedule include Texans vs. Colts (+3, 43.5), Bengals vs. Steelers (+3.5, 42.5), Chargers vs. Bills (-7, 50.5) and Rams vs. Broncos (+2.5, 45.5) on Sunday Night Football. The Rams are hoping to get wide receiver Puka Nacua (groin) back.
Before you lock in any Week 3 NFL picks, make sure you see what SportsLine's advanced computer model has to say.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 3 of the 2026 NFL season on a 53-41 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!
Now, the model has evaluated the latest NFL odds, simulated every snap for Week 3 of the 2026 NFL season, and the results are in.
One score prediction from SportsLine's model: The Denver Broncos beat the Los Angeles Rams 23-22 on Sunday at 8:20 p.m. ET. Denver covers (+2.5) 55% of the time, while the Under (45.5) hits as well.
In addition, the model is calling for an underdog to pull off a SHOCKING upset! Nailing these results is key to making profitable Week 3 NFL picks. You ABSOLUTELY NEED to see who to pick before locking in any Week 3 NFL score predictions!
What are the projected scores for every Week 3 NFL game? And which underdog shocks the NFL? ... Join SportsLine now to get NFL Week 3 score predictions, all from the model on a dominant 53-41 roll!
Don't miss out: All new SportsLine memberships include Paramount+ Premium -- a $13.99/month value -- for no extra cost! Join now and get it all.
GET VEGAS EXPERT PICKS FOR NFL, MLB, NBA, CBB, GOLF, NHL, HORSE RACING AND MORE - PLUS ADVANCED COMPUTER SIMULATIONS, WINNING TOOLS, AND MORE!
Written by Daniel Kohn
View expert profile
