Content on this page may include affiliate links. If you click and sign up/place a wager, we may receive compensation at no cost to you.
Week 2 of the 2026 NFL season features 14 Sunday matchups, and NFL bettors are looking for score predictions they can work off of to form spread, total, money-line and prop picks ahead of a massive Week 2 slate. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Some notable NFL spreads on the Week 2 NFL schedule include Bengals vs. Texans (-2.5, 45.5), Steelers vs. Patriots (-5, 41.5), Colts vs. Chiefs (-6.5, 46.5) on Sunday night and Giants vs. Rams (-7.5, 48) on Monday. Houston will be without Nico Collins (hamstring), while the Rams could be without Puka Nacua (groin) who is questionable.
Before you lock in any Week 2 NFL picks, make sure you see what SportsLine's advanced computer model has to say.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2026 NFL season on a 53-39 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!
Now, the model has evaluated the latest NFL odds, simulated every snap for Week 2 of the 2026 NFL season, and the results are in.
One score prediction from SportsLine's model: The Houston Texans beat the Cincinnati Bengals 26-21 on Sunday at 1 p.m. ET. Houston covers (-2.5) 56% of the time, while the Over (45.5) hits as well.
In addition, the model is calling for an underdog to pull off a SHOCKING upset! Nailing these results is key to making profitable Week 2 NFL picks. You ABSOLUTELY NEED to see who to pick before locking in any Week 2 NFL score predictions!
What are the projected scores for every Week 2 NFL game? And which underdog shocks the NFL? ... Join SportsLine now to get NFL Week 2 score predictions, all from the model on a dominant 53-39 roll!
Don't miss out: All new SportsLine memberships include Paramount+ Premium -- a $13.99/month value -- for no extra cost! Join now and get it all.
GET VEGAS EXPERT PICKS FOR NFL, MLB, NBA, CBB, GOLF, NHL, HORSE RACING AND MORE - PLUS ADVANCED COMPUTER SIMULATIONS, WINNING TOOLS, AND MORE!
Written by Daniel Kohn
View expert profile
