2026 NFL Week 4 odds, score predictions: SportsLine AI reveals picks for every game
SportsLine AI reveals its NFL picks against the spread, over/under and money line for every NFL game in Week 4
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Two teams with Super Bowl aspirations will be desperate to pick up win No. 1 as Week 4 of the NFL season kicks off on Thursday night. There will again be 14 games on Sunday and one on Monday. On Sunday, the Houston Texans look to get into the win column against the visiting Dallas Cowboys (+2.5), while the Los Angeles Chargers seek their first win against the Seahawks (-7) in Seattle. The highest O/U of any of the Sunday games is an AFC matchup between the Jacksonville Jaguars and the Cincinnati Bengals (O/U 51.5) at Cincinnati. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Week 4 ends with a 'Monday Night Football' matchup between the Atlanta Falcons vs. New Orleans Saints (-2.5). The Falcons are coming off a 35-14 win at Green Bay, while New Orleans dropped a 35-27 decision to the Las Vegas Raiders. Atlanta running back Bijan Robinson is coming off a dominating performance in which he rushed 29 times for 194 yards and two touchdowns against Green Bay.
Before making any Week 4 NFL picks, be sure to check out the NFL score predictions from the SportsLine's self-learning AI.
Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data then quantitatively evaluating the strength of the opponents defense by assigning a numeric value out of 100 called a matchup score.
Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see a 5-star rating on an Over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.
In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. It has nailed thousands of 4.5- and 5-star prop picks since the start of the 2023 season! Anyone who has followed it could be WAY UP!
After analyzing every game in Week 4, the AI says the Under hits in the Cardinals vs. Giants (+1, 44.5) matchup as Arizona wins 21-19 on average.
SportsLine AI has generated against the spread, over/under and money-line picks for every game in Week 4! In fact, the AI has generated several other HIGHLY-COVETED A+ picks! You ABSOLUTELY NEED to see the AI analysis before making any Week 4 NFL bets.
Which NFL bets do you need to make NOW for Week 4? And which must-see NFL picks are worthy of an A+ rating? ... Join SportsLine now to see the top 2026 Week 4 NFL picks, all from the self-learning SportsLine AI that has nailed a COLOSSAL 2,000+ top-rated picks since the start of last season!
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Written by Daniel Kohn
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