2026 NFL Week 2 odds, score predictions: SportsLine AI reveals picks for every game
SportsLine AI reveals its NFL picks against the spread, over/under and money line for every NFL game in Week 2
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After a week of surprise and intrigue, Week 2 of the NFL continues Sunday with 15 more games, including several key divisional matchups. Among the more intriguing is an NFC East clash between the Washington Commanders and Dallas Cowboys (-3.5) on Sunday afternoon. It has the highest O/U (50.5) of any Sunday game and is one of five divisional matchups of the week. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Week 2 ends with a 'Monday Night Football' matchup between the New York Giants and the Los Angeles Rams (-7.5). The Giants opened with a stunning 28-20 win over the Cowboys, while the Rams were dominated in a 27-7 loss to the 49ers in Melbourne, Australia. Puka Nacua (groin) is questionable for L.A., but the Rams could get back Aaron Donald. Sunday's largest spreads include Dolphins vs. 49ers (-12.5), Browns vs. Buccaneers (-8.5) and Saints vs. Ravens (-8.5). Meanwhile, the Eagles (-7) are the biggest road favorite as they visit Tennessee. The smallest spreads in Week 2 include Panthers vs. Falcons (+2.5) and Jaguars vs. Broncos (-2.5).
Before making any Week 2 NFL picks, be sure to check out the NFL score predictions from the SportsLine's self-learning AI.
Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data then quantitatively evaluating the strength of the opponents defense by assigning a numeric value out of 100 called a matchup score.
Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see a 5-star rating on an Over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.
In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. It has nailed thousands of 4.5- and 5-star prop picks since the start of the 2023 season! Anyone who has followed it could be WAY UP!
After analyzing every game in Week 2, the AI says the Under hits in the Packers vs. Jets (+3.5, 44.5) matchup as Green Bay wins 24-18 on average.
SportsLine AI has generated against the spread, over/under and money-line picks for every game in Week 1! In fact, the AI has generated several other HIGHLY-COVETED A+ picks! You ABSOLUTELY NEED to see the AI analysis before making any Week 1 NFL bets.
Which NFL bets do you need to make NOW for Week 2? And which must-see NFL picks are worthy of an A+ rating? ... Join SportsLine now to see the top 2026 Week 2 NFL picks, all from the self-learning SportsLine AI that has nailed a COLOSSAL 2,000+ top-rated picks since the start of last season!
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Written by Daniel Kohn
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