2026 Indianapolis 500 odds, picks: Projected IndyCar at The Brickyard leaderboard, predictions from proven model

The 2026 Indianapolis 500 will take place on Sunday at 12:45 p.m. ET at Indianapolis Motor Speedway, as The Greatest Spectacle in Racing celebrates its 110th running. Alex Palou won last year, ending Josef Newgarden's quest to three-peat, and the former tops the IndyCar Series standings. Those two are among nine past Indy champions looking to see another winner's circle at the 2026 Indy 500. Palou is the +250 favorite, followed by Pato O'Ward (+600) and Conor Daly (+750). Newgarden comes in at +1000, while Helio Castroneves is a +3000 longshot per the latest Indianapolis 500 odds as he seeks a record-breaking fifth victory.

Before making any 2026 Indianapolis 500 predictions, you NEED to see the latest 2026 Indy 500 picks from SportsLine's proven projection model.

Our proven projection model has simulated the race 10,000 times and came up with a surprising leaderboard. Developed by daily Fantasy pro and SportsLine predictive data engineer Mike McClure, this proprietary auto racing prediction computer model takes into account a slew of factors including track history and recent results. 

All told, the model has nailed a whopping 29 NASCAR winners since 2021 and hit 11 winners in 2025! Anyone who followed its lead on those auto racing picks could have seen HUGE returns.

Now, the model has dialed in on the 2026 Indy 500 and released its projections.

For the 2026 Indianapolis 500, we can tell you the model is high on Scott Dixon, even though he is a +1600 longshot in the latest 2026 Indianapolis 500 odds. He's a target for anyone looking for a HUGE payday. And a massive shocker: Conor Daly, who has four straight top 10 Indy 500 finishes and is one of the favorites at +750, stumbles big-time and barely cracks the top 10! There are far better values in the 2026 Indy 500 starting grid.

The model is also targeting TWO OTHER drivers with 2026 Indianapolis 500 odds of +1100 or longer to make a serious run at the checkered flag, including a massive longshot of at least +3000! Anyone who backs these drivers could hit it BIG. You ABSOLUTELY need to see who it is before locking in any IndyCar picks.

So who wins the 2026 Indy 500, and which long shots are a MUST-BACK? ... Join SportsLine right now to see the full projected Indianapolis 500 leaderboard, all from the model that has nailed 29 NASCAR winners since 2021 including 11 winners last year!