The 2025 Indianapolis 500 will take place on Sunday at 12:45 p.m. ET at Indianapolis Motor Speedway, as The Great American Race celebrates its 109th running. Josef Newgarden is the two-time defending champion and will try to become the first driver to win three straight Indy 500 races. Speaking of past champions, Helio Castroneves is seeking a record-breaking fifth win at this race, but a driver who has yet to prevail at The Brickyard tops the 2025 Indianapolis 500 odds. Pato O'Ward is the 5-1 favorite, followed by Alex Palou (11-2). Newgarden is at 10-1 to back in 2025 Indy 500 bets, while NASCAR's Kyle Larson is an 18-1 Indianapolis 500 longshot and will also try to complete "The Double" with a run in the NASCAR Coca-Cola 600 on Sunday.

Before making any 2025 Indianapolis 500 predictions, you NEED to see the latest 2025 Indy 500 picks from SportsLine's proven projection model.

Our proven projection model has simulated the race 10,000 times and came up with a surprising leaderboard. Developed by daily Fantasy pro and SportsLine predictive data engineer Mike McClure, this proprietary auto racing prediction computer model takes into account a slew of factors including track history and recent results.

The model began the 2025 NASCAR season by calling Chase Elliott to win for a +300 payout at the Clash at Bowman Gray. Then it predicted Kyle Larson's win in Miami for a +350 payout, and Christopher Bell's (+600) All-Star victory. In 2024, it nailed Larson to win in Las Vegas for a 21-5 sports betting payout and predicted Denny Hamlin's wins in Bristol at 5-1 and Richmond at 17-4. All told, the model has nailed a whopping 21 NASCAR winners since 2021.

It has been scorching hot when it comes to picking Formula 1 races dating back to 2021 as well. It nailed 10 victories across the 2021 and 2022 seasons and then forecasted Max Verstappen's rise to prominence by calling all 19 of his wins during the 2023 season and each of his first seven wins in 2024. In all, it has called 32 of the last 51 Formula One winners dating back to 2023. Anyone who followed the model's lead on those plays at sportsbooks and on betting apps could have seen huge returns.

Now, the model has dialed in on the 2025 Indy 500 and released its projections.

For the 2025 Indianapolis 500, we can tell you the model is high on Felix Rosenqvist, even though he is a 12-1 longshot in the latest 2025 Indianapolis 500 odds. He's a target for anyone looking for a HUGE payday. And a massive shocker: Josef Newgarden, the two-time defending champion, and one of the favorites, stumbles big-time and doesn't even crack the top five! There are far better values in the 2025 Indy 500 starting grid.

The model is also targeting TWO OTHER drivers with 2025 Indianapolis 500 odds of 12-1 or longer to make a serious run at the checkered flag! Anyone who backs these drivers could hit it BIG. You ABSOLUTELY need to see who it is before locking in any IndyCar picks.

So who wins the 2025 Indy 500? And which long shots are a MUST-BACK? ... Join SportsLine right now to see the full projected Indianapolis 500 leaderboard, all from the model that has nailed 21 NASCAR winners since 2021 and 32 Formula One winners since 2023!