A first-round matchup in the South Region of the 2024 NCAA Tournament takes place when the seventh-seeded Florida Gators take on the No. 10 seed Colorado Buffaloes at Gainbridge Fieldhouse in Indianapolis on Friday. Florida (24-11) is looking to record its ninth consecutive Round-of-64 victory since losing to BYU in double overtime in 2010. The Buffaloes (25-10) lost five of six NCAA Tournament games before defeating Boise State 60-53 in the First Four on Wednesday.

Tip-off is scheduled for 4:30 p.m. ET. The Gators are 1-point favorites in the latest Florida vs. Colorado odds, while the over/under for total points scored is 157.5.

Before making any Colorado vs. Florida picks or NCAA Tournament predictions, you need to check out the college basketball predictions from the SportsLine Projection Model. (See up-to-date odds for every game this week on our college basketball odds page.)

The model simulates every Div. I college basketball game 10,000 times. It entered the 2024 NCAA Tournament on a 148-106 roll on all top-rated college basketball picks dating back to last season, returning more than $1,700 for $100 players. It also has a strong 29-19 (+810) record on top-rated spread picks this season. Anyone following it has seen HUGE returns!

The model knows Florida is led offensively by Walter Clayton Jr., who is averaging 17.1 points this campaign. The junior guard reached the 20-point plateau 14 times, tying him for fourth in the SEC, and enters the NCAA Tournament with 600 points - the most by a Gator in one season since Nick Calathes scored 618 in 2008-09. Clayton is one of four players in the conference to average at least 17 points, three rebounds (3.6) and two assists (2.6) in 2023-24.

But the model also has taken into account that Colorado is making just its second appearance in the NCAA Tournament since 2016 and first since 2021, when it routed Georgetown in its opener before falling to Florida State in the Round of 32. The Buffaloes' triumph over Boise State on Wednesday was their ninth in 10 games and a program record 25th of the season. Senior forward Tristan da Silva scored a game-high 20 points against the Broncos and junior guard KJ Simpson, who leads Colorado with a 19.6-point average, registered his third double-double of the campaign with 19 points and 11 rebounds.

For Friday, the model has set its sights on Florida vs. Colorado in the 2024 NCAA Tournament. We can tell you the model is leaning Under on the point total, and it also says one side of the spread hits well over 50% of the time. You ABSOLUTELY need to see the model before locking in any college basketball picks.

Who wins Florida vs. Colorado, and which side of the spread hits well over 50% of the time? ... Join SportsLine right now to find out which side of the Colorado vs. Florida spread you should be all over Friday, all from the model on a 148-106 roll on college basketball picks!